30 year old G10 P4 L2 A5 D2 came with h/o 1.5 months of amenorrhoea with c/o bleeding PV since 2 weeks a/wpain,c/o fatigue since 2 days.
History of present pregnancy : 1st trimester – conceived spontaneously, pregnancy detected by UPT 1 week back, confirmed by USG.
G10 P4 L2 A5 D2
1st – concieved spontaneously, breech delivery, male died at 22 days. Cause of death – jaundice
2nd- conceived spontaneously, spontaneous abortion at 2 months, D&C done
3rd – conceived spontaneously, spontaneous abortion at 2.5 months
4th – conceived spontaneously, spontaneous abortion at 1.5 months
5th – conceived spontaneously, spontaneous abortion at 3 months
6th – conceived spontaneously, cervical encerclage at 4th month, FTND, female baby died at 2 years. Cause of death – Tuberculosis
7th – conceived spontaneously, FTND, female baby, 9 years of age, currently active and healthy
8th – concieved spontaneously, FTND, female baby, 8 years of age, currently active and healthy.
9th – concieved spontaneously, consumption of MTP pills at 1.5 months, complete abortion.
10th – conceived spontaneously, present one.
LMP – 9/3/19
EDD – 16/12/19
POG – 6 weeks 2 days
Past cycles – 3-5/30, regular, moderate flow, No pain , No clots.
H/o of Laproscopic sterilization done in 2011 and 2015
GENERAL PHYSICAL EXAMINATION:
Pulse – 84 bpm
BP – 130/80 mm Hg
SYSTEMIC EXAMINATION :
CVS – S1, S2 heard. No murmurs
RS – B/L normal vesicular breath sounds heard. No added sounds
P/A – Soft, non tender. No organomegaly
P/S – No discharge, cervix healthy
P/V – uterus bulky, corresponds to 8 weeks size.
|Hb – 12.4gm/dl (12-15 gm/dl) |
TLC – 11410 cells/cumm (4000 – 11000 cells/cumm)
DC: Neutrophils – 59.1
Lymphocytes – 34.9
Eosinophils – 1.6
Monocytes – 4.1
Basophils – 0.3
PCV – 38.9 (36-46%)
Rbc count – 5.08 million/cumm (3.8-4.8 million/cumm)
- Chromosomal abnormality
- Inherited thrombophilias
- Anti -phospholipid antibody syndrome
- Poorly controlled diabetes
- Thyroid autoantibodies
- Luteal phase defect
- Polycystic ovarian syndrome
30 Year old Gravida 10 Para 4 Living 2 Abortion 5 Death 2 with 6 weeks 2 days of gestation with BicornuateUnicollis Uterus with implantation in the left horn.
MTP with Laproscopic bilateral salpingectomy under GA.
BicornateUnicollis uterus noted
Right hydrosalpinx noted
Fallope rings of old tubectomy present on the right tube
Left tube not tubectomized
Bilateral salpingectomy done
Products of conception present in the left horn
6 weeks size uterus noted
Products sent for HPE.
Congenital uterine anomalies result from the abnormal formation, fusion, or resorption of Müllerian duct during fetal life.
They are present in, 2–8% of infertile women, and 5–30% of women with a history of miscarriage(1).
Premature deliveries (29%), spontaneous first-trimester abortions (24%), ectopic pregnancies (3%), abnormal fetal presentations (23%) and a high cesarean section rate (27.5%) occurred in those patients.
In 30% of the patients, cervical incompetence was diagnosed. Improved obstetric outcomes occurred in patients treated with cervical cerclage(5).
Although uterine anomalies are associated with adverse reproductive outcomes, healthy reproductive outcomes are possible.
Females with obstructive uterine anomalies tend to present during adolescence due to pelvic pain or dysmenorrhea, and those with non obstructive uterine anomalies may not be identified until evaluation of pregnancy loss, an obstetric complication, or infertility is initiated.
Imaging modalities to evaluate congenital uterine anomalies include two-dimensional ultrasonography (2DUS), three-dimensional ultrasonography (3DUS), hysterosalpingography, saline infusion ultrasonography, and magnetic resonance imaging (MRI).
As 3DUS is increasingly utilized in pelvic imaging, this modality is proving to be highly accurate in diagnosing uterine anomalies and may be equivalent to MRI(2).
Widely diverging horns seen on HSG may suggest a bicornuate uterus and an intercornual angle greater than 105 degrees suggests bicornuate uterus, whereas one less than 75 degrees indicates a septate uterus. However, MRI may be necessary to define fundal contour.
With this, an intrafundal downward cleft measuring greater than or equal to 1 cm is indicative of bicornuate uterus, whereas a cleft depth < 1 cm indicates a septate uterus(9)
Over the years, surgical treatments have been offered to women diagnosed with congenital uterine anomalies.
Abdominal metroplasty is associated with significant morbidities, such as prolonged hospital stay, long post-op recovery, intra-abdominal adhesions, uterine rupture in subsequent pregnancies etc.(3) Strassman metroplasty provides an important decrease in the percentage of fetal loss (8-12%) compared to patients without surgical treatment (70-96%).(7) It is a unification procedure performed to correct the two smaller uterine cavities into a more spacious single cavity. Improved reproductive performance was reported after unification metroplasty. Laparoscopic route can be adopted for this procedure with all the advantages of minimally invasive surgery. The laparoscopic route provides better magnification, lower tissue drying, reduced infections, lesser adhesions, shorter hospital stay, and quicker recovery. (6) The actual benefit of metroplasty for a bicornuate uterus, however, has not been tested in a controlled clinical trial and metroplasty for now should be reserved for women in whom recurrent pregnancy loss occurs with no other identifiable cause(8).
According to the CREST study, the 10-year failure rate is 18.5 per 1000 procedures.The pregnancy rates were highest following laparoscopic Hulka clip sterilization and lowest following monopolar coagulation and postpartum salpingectomy (4)
- Chan, Yee Yin (2019) Study to evaluate the prevalence, importance, and treatment of women with congenital uterine anomalies. PhD thesis, University of Nottingham.
- Rackow B.W. (2019) Congenital Uterine Anomalies. In: Stadtmauer L., Tur-Kaspa I. (eds) Ultrasound Imaging in Reproductive Medicine. Springer, Cham
- G. Zlopaša,S. Škrablin ,D. Kalafatić ,V. Banović ,J. Lešin.Uterine anomalies and pregnancy outcome following resectoscope metroplasty. Volume 98. International journal of gynaecology and obstetrics; 2007.
- Gossman W, Canela CD, Nama N. Tubal Sterilization StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan
- Golan A,Langer R, Neuman M, Wexler S, Segev E, David MF,Obstetric outcome in women with congenital uterine malformations, Journal of reproductive medicine, 1992 Mar;37(3):233-6.
- SDS Karthik, Alka Kriplani, Reeta Mahey,Garima Kachhawa, Successful reproductive outcome after Laparosopic strassman metroplasty, Journal of Human reproductive sciences, 2017 Jul-Sep; 10(3): 231–234.
- R. Tomasz, M. Marta, and B. Aleksandra, “Clinical effectiveness of Strassman operation in the treatment of bicornuate uterus,” Ginekologia Polska, vol. 80, no. 2, pp. 88–92, 2009.
- M. Sugiura-Ogasawara, B. L. Lin, K. Aoki et al., “Does surgery improve live birth rates in patients with recurrent miscarriage caused by uterine anomalies?” Journal of Obstetrics & Gynaecology, vol. 35, no. 2, pp. 155–158, 2015.
- K. L. Reuter, D. C. Daly, and S. M. Cohen, “Septate versus bicornuate uteri: Errors in imaging diagnosis,” Radiology, vol. 172, no. 3, pp. 749–752, 1989.